Topics of Interest

New Medication for Heavy Menstrual Bleeding

Tranexamic Acid Treatment for Heavy Menstrual Bleeding

Journal: Obstetrics and Gynecology. 2010;116:865-75

Authors: Lukes AS, Moore KA, Muse KN, Gersten JK, Hecht BR, Edlund M, Richter HE, Eder SE, Attia GR, Patrick DL, Rubin A, Shangold GA

Study from: Carolina Women’s Research and Wellness Center, Durham, North Carolina

Problem: Heavy menstrual bleeding is a common problem for women and often leads to surgery or other treatments. Birth control pills help some women, but not all. Another oral medication option would be welcome.

Study: Adult women with heavy menstrual bleeding were randomized to receive either tranexamic acid (Lysteda) or a placebo for up to 5 days per menstrual cycle for six cycles. The amount of bleeding and health-related quality of life was measured using a questionnaire.

Results: Women who received tranexamic acid had a significant reduction in menstrual blood loss and this reduction was considered meaningful to women, in that they had improvements in limitations in social or leisure and physical activities and work inside and outside the home. Gastrointestinal side-effects were no more than with the placebo.

Authors’ Conclusions: Oral tranexamic acid treatment was well tolerated and significantly improved both menstrual blood loss and health-related quality of life in women with heavy menstrual bleeding.

Dr. Parker’s Comments: Tranexamic acid has been available in Europe for more than 15 years and has been found to be an effective treatment option for many women with heavy bleeding. Unfortunately, the drug had been around so long that it could not be patented in the US (the down side of the patent system). Recently, a slightly different compound was able to be patented and is now available here.

The medication works by allowing the blood to clot faster, so less is lost. There is some evidence that this medication also works for women with fibroids and may be worth trying, since there are minimal side-effects.


Disclaimer: The ideas, procedures and suggestions contained on this web site are not intended as a substitute for consulting with your physician. All matters regarding your health require medical supervision.


  1. Posted January 2, 2011 at 9:05 pm | Permalink

    Terrific work! This is the type of information that should be shared around the web. Shame on the search engines for not positioning this post higher!

  2. Cynthia
    Posted May 28, 2011 at 7:36 am | Permalink

    Where can I get this medication? Can my doctor perscribe it?

Fibroid Doctor William H. Parker

Dr. William H. Parker is a board-certified Fellow in the American College of Obstetricians and Gynecologists. Dr. Parker is an internationally recognized expert in fibroid surgery and research. Based in San Diego, California, he is considered one of the best fibroid surgeons for abdominal and laparoscopic myomectomy in the United States and abroad. He has been chosen for Best Doctors in America and Top Doctors every year beginning in the late 90's.

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