Leiomyoma simultaneously impair endometrial BMP-2-mediated decidualization and anticoagulant expression through secretion of TGF-β3.
Journal: Journal of Clinical Endocrinology and Metabolism. 2011;96:412-21.
Authors: Sinclair DC, Mastroyannis A, Taylor HS.
Study from: Yale University School of Medicine
Problem: Women with submucous fibroids have decreased fertility, increased miscarriage rates, and heavy menstrual bleeding. Why this happens has not been well understood. The authors tested to see if proteins that interfere with fertility and/or cause heavy bleeding were produced by fibroids.
Study: Sophisticated laboratory tests were performed on fibroids and normal uterine muscle to see if the cells made proteins that could cause infertility or heavy bleeding.
Results: Fibroids make different amounts of proteins than normal uterine muscle and these proteins make it more difficult for a fertilized egg to stick to the uterine lining. Fibroids also make other proteins that interfere with the blood clotting in the uterine lining which causes heavy bleeding.
Dr. Parker’s Comments: This is cutting edge science from the fertility group at Yale. Using techniques from molecular biology, the authors showed that fibroids make proteins that both decrease fertility and increase menstrual bleeding. We knew these effects existed, but now we have a better idea as to why.



One Comment
Joy,
I totally understand your dilemma – it is a story I hear all the time from women I see for second, third, fourth opinions. You do have options, but you will need to find qualified doctors to provide them for you.
One option is an endometrial ablation; cauterization of the uterine lining cells to stop the bleeding. See more about this here: http://www.fibroidsecondopinion.com/hysteroscopic-myomectomy/
A similar technique, hysteroscopic myomectomy, may be used to remove part of the fibroid in order to gain access to the uterine cavity so that the ablation can be performed.
Another option is uterine artery embolization. This procedure is performed by interventional radiologists and has excellent results for heavy bleeding, around 90% success rates. You can see more about this here: http://www.fibroidsecondopinion.com/uterine-artery-embolization/
And, as you mention, myomectomy can remove the fibroid and also eliminate the heavy bleeding without a hysterectomy. Based on the size of the fibroid, this should be very straight-forward in the hands of a gynecologist who regularly performs this procedure.
Hopefully, you can find someone to provide you these other options. Hysterectomy should not be necessary.
Bill Parker, MD